More specifically, we investigate how dynein is regulated by LIS1 and related proteins in adult mammalian systems. We are particularly interested in how these dynein regulators impact axonal transport, a process vital to the maintenance of neural circuits and neural health. Currently, we are studying the effect of LIS1 missense mutations in cultured neurons and exploring the impact of LIS1 depletion in mice. We are defining the role of LIS1 in both neurons and glial cells in the adult mouse nervous system. |